Skip Navigation LinksHome > October 2012 - Volume 31 - Issue 10 > Photo-Activated Riboflavin Therapy of Refractory Corneal Ulc...
doi: 10.1097/ICO.0b013e31823f8f48

Photo-Activated Riboflavin Therapy of Refractory Corneal Ulcers

Panda, Anita MD, FAMS, FICS*; Krishna, Sasikala N. DOMS*; Kumar, Sandeep MS

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Purpose: To evaluate the therapeutic effect of photo-activated riboflavin (PAR) for treating refractory corneal ulcers.

Methods: Seven eyes with infectious keratitis, presented with a gradually deteriorating, vision-threatening, corneal ulcer, despite intense antimicrobial therapy, were treated with PAR. The surgical procedure was deepithelialization of the affected corneas followed by UV-A riboflavin (B2) cross-linking. Local antimicrobial therapy was continued after the procedure.

Results: In all cases, the progression of corneal melting was halted after PAR treatment. Emergency keratoplasty was not necessary in any of the 7 eyes presented. More importantly, all the ulcers were healed without significant vascularization.

Conclusion: PAR is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty and should be considered as a potential adjuvant therapeutic tool in such eyes.

© 2012 Lippincott Williams & Wilkins, Inc.


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