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Corneal Thickness Measurement Using Orbscan, Pentacam, Galilei, and Ultrasound in Normal and Post-Femtosecond Laser In Situ Keratomileusis Eyes

Park, Se-Hoon MD*; Choi, Suk-Kyue MD*; Lee, Doh MD, PhD*; Jun, Eun-Jung MD, PhD; Kim, Jin-Hyoung MD, PhD*

doi: 10.1097/ICO.0b013e31823d03fc
Clinical Science

Purpose: To compare corneal pachymetry assessment using slit scanning imaging (Orbscan), rotating Scheimpflug imaging (Pentacam), dual Scheimpflug system (Galilei), and ultrasound pachymetry in normal and post-femtosecond (FS) laser in situ keratomileusis (LASIK) eyes.

Methods: Sixty eyes of 60 patients were enrolled for this study, which consisted of 30 unoperated eyes (normal corneas) and 30 eyes after FS-LASIK (post-LASIK corneas). Central corneal thickness was measured sequentially using Orbscan II, Pentacam, Galilei, and ultrasound pachymetry, and the average value of measurements obtained by the 4 different methods were compared in each group.

Results: In normal corneas, corneal thickness measurements were not different by all 4 methods [P = 0.202, 1-way analysis of variance (ANOVA)]. In post-LASIK corneas, the measurement was significantly different among those achieved by 4 methods (P < 0.001, 1-way ANOVA). Orbscan measurement was thinner than those yielded by Galilei, Pentacam, or ultrasound pachymetry with average of 47.7, 38.5, and 34.4 μm, respectively (all P values < 0.001, 1-way ANOVA and the Tukey multiple comparisons test) in post-LASIK corneas. Orbscan, Pentacam, and Galilei measurements showed good agreement with ultrasound pachymetry data in both groups, except Orbscan data in post-LASIK corneas showed a statistically significant difference from ultrasound pachymetry measurements (P value = 0.001, 1-way ANOVA and the Tukey multiple comparisons test).

Conclusions: Any of central corneal thicknesses obtained by all 4 measurement modalities might be acceptable before refractive surgery. However, in post-FS-LASIK eyes, measurements using Orbscan were thinner than those obtained with other modalities; in contrast, those with Pentacam or Galilei were comparable with ultrasound pachymetry.

*Department of Ophthalmology, Ilsan Paik Hospital, Inje University, Kyunggi-do, South Korea

Department of Ophthalmology, St. Paul Hospital, Catholic University, Seoul, South Korea

Reprint: Jin-Hyoung Kim, Department of Ophthalmology, Ilsan Paik Hospital, Inje University Medical College, 2240 Dae Wha-dong, Ilsan-ku, Koyang, Kyunggi-do 411-706, Korea (e-mail:

The authors state that they have no proprietary interest in the products named in this article.

Received January 20, 2011

Accepted August 24, 2011

© 2012 Lippincott Williams & Wilkins, Inc.