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Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using LenStar LS900, Pentacam, and Visante AS-OCT

O'Donnell, Clare PhD, MBA, MCOptom, FAAO*,†; Hartwig, Andreas Dipl Ing (FH); Radhakrishnan, Hema PhD, MCOptom†

doi: 10.1097/ICO.0b013e31823f8e2f
Clinical Science

Purpose: To compare central corneal thickness (CCT) and anterior chamber depth (ACD) measured using 3 different techniques.

Methods: CCT and ACD were measured in one eye of 27 healthy subjects (age, mean ± SD: 34 ± 7 years), using the LenStar LS900, Pentacam, and Visante AS-OCT. The agreement between the measurement techniques was assessed using the coefficient of agreement (CoA) and the 95% limits of agreement (LoA).

Results: Mean ± SD values for CCT using the LenStar, Pentacam, and Visante were 550.7 ± 37.4 μm, 542.7 ± 37.9 μm, and 556.7 ± 44.4 μm, respectively (P = 0.005). Plots of differences against means displayed relatively good agreement between the Pentacam and LenStar (CoA, 19.97 μm; LoA, 15.53 μm to −24.40 μm), poorer agreement between the LenStar and Visante (CoA, 31.26 μm; LoA, 40.78 μm to −21.74 μm), and agreement was poor between the Pentacam and Visante (CoA, 37.36 μm; LoA, 25.61 μm to −49.11 μm). Mean ± SD values for ACD using the LenStar, Pentacam, and Visante were 2.93 ± 0.30 mm, 2.96 ± 0.32 mm, and 3.03 ± 0.29 mm, respectively (P < 0.001). Relatively good agreement for ACD measures was observed between the Pentacam and LenStar (CoA, 0.08 mm; LoA, 0.12 to −0.04 mm), poor agreement was obtained between the Visante and LenStar (CoA, 0.13 mm; LoA, 0.21 to −0.06 mm), and agreement was also poor between the Pentacam and Visante (CoA, 0.14 mm; LoA, 0.11 to −0.17 mm).

Conclusions: Our data show that the LenStar, Pentacam, and Visante provide measurements that are in agreement with published values for CCT and ACD in human subjects. Although reasonable agreement for CCT and ACD was found between the Pentacam and LenStar, agreement was poorer between the Visante and LenStar and between the Visante and Pentacam. Thus, CCT and ACD measures from these instruments should not be used interchangeably.

*Optegra Eye Sciences, Optegra Manchester Eye Hospital, Manchester, United Kingdom

Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.

Reprints: Andreas Hartwig, Faculty of Life Sciences, University of Manchester, Carys Bannister, PO Box 88, Manchester M60 1QD, United Kingdom (e-mail: andreas.hartwig@firma-hartwig.de).

The authors state that they have no proprietary interest in the products named in this article.

Received April 18, 2011

Accepted August 24, 2011

© 2012 Lippincott Williams & Wilkins, Inc.