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Cornea:
doi: 10.1097/ICO.0b013e31823f0905
Clinical Science

“In Situ” Corneal and Contact Lens Thickness Changes with High-Resolution Optical Coherence Tomography

González-Méijome, Jose M. OD, PhD, FIACLE*,†; Cerviño, Alejandro PhD†,‡; Peixoto-de-Matos, Sofia C. OD*,†,§; Madrid-Costa, David PhD; Jorge, Jorge PhD*,†; Ferrer-Blasco, Teresa PhD†,‡

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Abstract

Purpose: To show the use of high-resolution spectral-domain optical coherence tomography (HR-SOCT) for the in situ evaluation of epithelial, stromal, and contact lens (CL) thickness changes under closed-eye conditions without lens removal.

Methods: Eight young healthy patients wore a thick soft CL for 90 minutes under closed-eye conditions, and measures of epithelial and stromal corneal thickness were obtained at regular intervals using a HR-SOCT (Copernicus HR; Optopol Tech. SA, Zawiercie, Poland).

Results: Minimal changes in epithelial thickness were detected with a transient statistically significant increase in epithelial thickness in the fellow control eye 30 minutes after insertion (P = 0.028). A significant and progressive increase in stromal thickness up to 8% after 90 minutes of lens wear was observed at a constant rate of 2.5% every 30 minutes, being statistically significant in all observations (P < 0.001). Fellow control eyes also showed a significant increase in stromal thickness at a much lower rate of 0.5% every 30 minutes. Lens thickness decreased significantly by 2% after 90 minutes of lens wear under closed-eye conditions (P < 0.001). Individual analysis showed that all eyes displayed stromal swelling, whereas only half of them showed epithelial swelling.

Conclusions: Increase in stromal thickness and a slight decrease in lens thickness were observed in response to a hypoxic stimulus under closed-eye conditions. HR-SOCT is a powerful tool to investigate in vivo the physiological interactions between cornea and CLs.

© 2012 Lippincott Williams & Wilkins, Inc.

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