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Central Corneal Thickness Measurements With Fourier-Domain Optical Coherence Tomography Versus Ultrasonic Pachymetry and Rotating Scheimpflug Camera

Ishibazawa, Akihiro MD; Igarashi, Sho MD; Hanada, Kazuomi MD; Nagaoka, Taiji MD; Ishiko, Satoshi MD; Ito, Haruna MD; Yoshida, Akitoshi MD

doi: 10.1097/ICO.0b013e3181d00800
Clinical Science

Purpose: To compare the accuracy and repeatability of Fourier-domain optical coherence tomography (FD-OCT) with ultrasonic pachymetry (USP) and a rotating Scheimpflug camera for measuring the central corneal thickness (CCT).

Methods: The CCT was measured in 30 subjects (30 normal corneas) by the same examiner using RTVue-100 FD-OCT with an anterior segment adaptor, Pentacam rotating Scheimpflug camera, and SP-2000 USP. Two examiners obtained one FD-OCT measurement from 10 eyes of 5 subjects to assess interexaminer reproducibility.

Results: The mean CCT (±SD) measured by FD-OCT, USP, and the Pentacam were 530 ± 33, 544 ± 34, and 552 ± 35 μm, respectively. Significant correlations were found between FD-OCT and USP (r = 0.97; P < 0.0001), FD-OCT and Pentacam (r = 0.97; P < 0.0001), and USP and Pentacam (r = 0.96; P < 0.0001). Pairwise comparisons showed that the FD-OCT CCT measurement was significantly thinner than those of the other 2 methods (P < 0.001 for all comparisons). Regarding intraexaminer repeatability, the intraclass correlation coefficients ranged between 0.97 and 0.98. There was high repeatability of the CCT measurements with all methods. FD-OCT also had high interexaminer reproducibility (intraclass correlation coefficient = 0.98).

Conclusions: RTVue-100 FD-OCT may be a useful alternative for measuring the CCT; however, it significantly underestimates the CCT compared with the USP and the Pentacam with slight differences. Although highly correlated, the measurements are not directly interchangeable in clinical practice.

Author Information

From the Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Received for publication September 8, 2009; revision received December 6, 2009; accepted December 13, 2009.

The authors have no financial interest in any aspect of this report.

Reprints: Sho Igarashi, Department of Ophthalmology, Asahikawa Medical University, 2-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan (e-mail:

© 2011 Lippincott Williams & Wilkins, Inc.