Skip Navigation LinksHome > May 2010 - Volume 29 - Issue 5 > Mitomycin C Does Not Inhibit Exacerbation of Granular Cornea...
doi: 10.1097/ICO.0b013e3181c3258a
Clinical Science

Mitomycin C Does Not Inhibit Exacerbation of Granular Corneal Dystrophy Type II Induced by Refractive Surface Ablation

Ha, Byoung Jin MD*; Kim, Tae-im MD†‡; Choi, Seung-il PhD†‡; Stulting, R Doyle MD, PhD§; Lee, Dong Ho MD¶ ; Cho, Hyun-Soo PhD‖; Kim, Eung Kweon MD, PhD†‡

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Purpose: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.

Methods: Ten eyes of patients with GCD II who underwent refractive corneal surface ablation with MMC were compared with 10 eyes that were not treated with MMC. Best spectacle-corrected visual acuity, the degree of corneal opacity, and contrast sensitivity were evaluated at least 3 years after surgery. Corneal opacities were quantified using Pentacam densitometry maps.

Results: No measured between-group value showed a statistically significant difference.

Conclusion: Simultaneous application of MMC does not prevent exacerbation of GCD II after refractive corneal surface ablation.

© 2010 Lippincott Williams & Wilkins, Inc.


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