Cornea

Skip Navigation LinksHome > April 2010 - Volume 29 - Issue 4 > The White Caruncle: Sign of a Keratinous Cyst Arising From a...
Cornea:
doi: 10.1097/ICO.0b013e3181b55b5c
Case Report

The White Caruncle: Sign of a Keratinous Cyst Arising From a Sebaceous Gland Duct

Jakobiec, Frederick A MD, DSc*†; Mehta, Manisha MD*†; Greenstein, Scott H MD*‡; Colby, Kathryn MD, PhD*§

Collapse Box

Abstract

Purpose: To describe an acquired, smooth white lesion of the caruncle and to underscore the role of subsurface keratinizing squamous epithelium in its formation.

Methods: Clinical photographic documentation, histopathologic evaluation, and immunohistochemical staining of an excised specimen from a 25-year-old woman.

Results: A cyst was found that was lined by keratinizing squamous epithelium without a keratohyaline layer (trichilemmal keratinization), typical of lesions of the pilosebaceous unit. A portion of the cyst's lining was replaced by granulomatous inflammation resulting from an earlier spontaneous partial rupture. Ki-67 immunolabeling demonstrated relatively few nuclei in S-phase (DNA synthesis) in comparison with the overlying epithelium, thereby suggesting an obstructive, nonproliferative cause for the cyst.

Conclusion: A white caruncular lesion is a very rare finding according to the literature. It is most likely caused by a cyst lined by squamous epithelium elaborating trichilemmal-type keratin. A sebaceous gland duct was established as the source for the current lesion.

© 2010 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.