Skip Navigation LinksHome > August 2009 - Volume 28 - Issue 7 > Immunotactoid Microtubular Corneal Deposits in Bilateral Par...
doi: 10.1097/ICO.0b013e318191449a
Case Report

Immunotactoid Microtubular Corneal Deposits in Bilateral Paraprotein Crystalline Keratopathy

Singh, Kamaljeet MBBS, MD

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Purpose: To report an ultrastructurally distinct form of paraprotein crystalline keratopathy.

Methods: Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed.

Results: The transmission electron microscopy showed “immunotactoid” extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core.

Conclusions: Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.

© 2009 Lippincott Williams & Wilkins, Inc.


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