You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Combined Use of Superficial Keratectomy and Subconjunctival Bevacizumab Injection for Corneal Neovascularization

Qian, Cynthia Xin-ya MD*; Bahar, Irit MD†; Levinger, Eliya MD†; Rootman, David MD, FRCSC†

doi: 10.1097/ICO.0b013e31817c41e3
Case Report

Purpose: To report the effect of superficial keratectomy combined with subconjunctival bevacizumab injection in 2 cases of corneal neovascularization (NV).

Methods: An interventional case series was undertaken on 2 patients with corneal NV: 1 due to sclerokeratitis secondary to rheumatoid arthritis and the other due to Terrien marginal degeneration. Both patients underwent superficial keratectomy combined with subconjunctival bevacizumab injection (2.5 mg/0.1 mL).

Results: Corneal NV regressed with the surgical removal and showed no signs of recurrence after 3 months of follow-up. Both patients reported dramatic subjective improvement in their vision within 1-2 weeks. Best corrected visual acuity improved in 1 patient.

Conclusion: The combination of superficial keratectomy with subconjunctival injection of bevacizumab may offer a new strategy for the treatment of superficial corneal NV.

Author Information

From the *Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada; and †Department of Ophthalmology, Toronto Western Hospital, Toronto Ontario, Canada.

Received for publication November 16, 2007; revision received March 23, 2008; accepted April 14, 2008.

Reprints: Cynthia Xin-ya Qian, Department of Ophthalmology, University of Montreal, Hôspital Notre-Dame-CHUM (Centre Hospitalier Universitaire de Montreal), 1560, sherbrooke street E, Montreal, Quebec, H2L 4M1 (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.