Skip Navigation LinksHome > December 2007 - Volume 26 - Issue 10 > Fibrin Glue for Opposing Wound Edges in “Top Hat” Penetratin...
Cornea:
doi: 10.1097/ICO.0b013e318151f8e8
Basic Investigation

Fibrin Glue for Opposing Wound Edges in “Top Hat” Penetrating Keratoplasty: A Laboratory Study

Bahar, Irit MD; Kaiserman, Igor MD, MSc, MHA; Slomovic, Allan MA, MD, FRCSC; McAllum, Penny MBChB, FRANZCO; Rootman, David MD, FRCSC

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Abstract

Purpose: To evaluate the advantages of fibrin glue for opposing wound edges in Top Hat penetrating keratoplasty (PKP).

Methods: Twenty human corneoscleral rims were mounted on an artificial anterior chamber. Eight corneas underwent traditional PKP, 6 underwent Top Hat PKP, and 6 underwent Top Hat PKP by using fibrin glue for opposing wound edges. Mechanical stability was evaluated after placement of 8 and 16 interrupted sutures. Wound bursting pressure and induced astigmatism were evaluated.

Results: In the traditional PKP group, wound bursting pressure was 25.2 and 59.1 mm Hg after placement of 8 and 16 sutures, respectively. In the Top Hat PKP, leakage occurred at 57.6 and 103.8 mm Hg after placement of the 8 and 16 sutures, respectively. In the Top Hat PKP + fibrin glue group, wound leakage occurred at 144.6 mm Hg after placement of the 8 sutures and at >158 mm Hg after placement of 16 sutures. The Top Hat PKP + fibrin glue group induced astigmatism of 2.5 D, whereas the traditional PKP group and the Top Hat PKP group showed an induced astigmatism of 3.1 D each.

Conclusions: The use of fibrin glue in Top Hat PKP was found to be more mechanically stable than traditional sutures.

© 2007 Lippincott Williams & Wilkins, Inc.

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