To elucidate the natural history and epidemiology of adenoviral keratoconjunctivitis as seen in a tertiary care eye clinic.
In a retrospective observational case series design, the medical records of 54 consecutive patients seen over a 6-year period at the Dean McGee Eye Institute (DMEI) with a diagnosis of adenoviral keratoconjunctivitis were analyzed retrospectively. The main outcome measure was the duration of symptomatic subepithelial corneal infiltrates following onset of acute conjunctivitis.
Annual case numbers ranged from 3 each in 1997 and 1998 to 26 in 2000. No more than 5 new cases presented in any single month, and no seasonal predominance was evident. The median duration of disease was 5 weeks, but the mean was 23.4 weeks, reflecting a subset of patients with a prolonged course. Indeed, 14 (25.9%) of 54 patients demonstrated symptomatic subepithelial corneal infiltrates for more than 45 days from the first examination for conjunctivitis.
These data suggest a significant level of long-term morbidity for adenoviral keratoconjunctivitis.
From the Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Received for publication January 21, 2005; revision received March 30, 2005; accepted April 9, 2005.
Supported by a Lew R. Wasserman Merit Award to J.C. from Research to Prevent Blindness, New York, NY, and US Public Health Service Grants EY13124 and EY12190.
Neither of the authors has any financial or proprietary interest in any material or instrument used in this study.
Reprints: James Chodosh, MD, DMEI-OUHSC, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104 (e-mail: firstname.lastname@example.org).