Skip Navigation LinksHome > August 2005 - Volume 24 - Issue 6 > Surgical Glove-Associated Diffuse Lamellar Keratitis
Clinical Sciences

Surgical Glove-Associated Diffuse Lamellar Keratitis

Hoffman, Richard S MD*; Fine, I Howard MD*; Packer, Mark MD*; Reynolds, Tony P COT†; Bebber, Cherie Van RN†

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Purpose: To demonstrate a potential cause of a prolonged epidemic of diffuse lamellar keratitis (DLK).

Method: This retrospective review analyzed an epidemic of diffuse lamellar keratitis over a 3-year period in a single surgery center. Altering the brand of surgical gloves used during surgery was associated with an elimination of the DLK epidemic. Optical microscopy, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and Fourier transform infrared (FTIR) spectroscopy were performed on both brands of surgical gloves to allow for comparisons and determine possible surface contaminants responsible for the DLK outbreaks.

Results: The incidence of DLK during the epidemic ranged from 2% to 38% on a quarterly basis for the 3-year period. A change in the brand of surgical gloves resulted in a cessation of DLK. Surface analysis of both brands of gloves revealed extensive silicone oil contamination on the internal and external surfaces of the DLK-associated gloves and insignificant amounts of silicone oil on the external surface of the DLK-free gloves.

Conclusion: Silicone oil contamination of surgical gloves appears to be associated with epidemic DLK.

© 2005 Lippincott Williams & Wilkins, Inc.


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