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Baseline Donor Characteristics in the Cornea Donor Study

Cornea Donor Study Group

Cornea:
Clinical Sciences
Abstract

Purpose: The Cornea Donor Study (CDS) is an ongoing study that is being conducted to determine whether donor age is related to long-term corneal graft survival. Characteristics of the donor population have been evaluated with respect to donor age, endothelial cell density, and death to preservation interval.

Methods: Within the context of a prospective, double-masked, controlled trial, 1101 donor corneas were assigned without regard to donor age.

Results: Slit-lamp characteristics of the donor corneas showed little variation with donor age, except for the presence of corneal arcus. As death to preservation time decreased, fewer epithelial abnormalities and a lower frequency of stromal edema and Descemet folds were observed. There was little change in the mean of the endothelial cell density with donor age beyond age 60, despite variation.

Conclusion: With respect to donor age, there was little difference in either the slit-lamp characteristics or endothelial cell density of the donor corneas. Fewer epithelial abnormalities were observed with shorter death to preservation time.

Author Information

Received for publication February 4, 2004; revision received August 12, 2004; accepted August 16, 2004.

*A list of the writing committee and the investigators and coordinators who participated in the study appears in the Appendix.

Supported by a cooperative agreement from the National Eye Institute, National Institutes of Health, U10 EY12358. Additional support provided by Eye Bank Association of America, Cornea Society, Tissue Banks International, Vision Share, Inc., Bausch & Lomb, Katena Products, Inc., Konan Medical Corp., ViroMed Laboratories, Inc., Eye Bank for Sight Restoration, Lions Eye Bank of Oregon, Midwest Eye-Banks and Transplantation Center (Michigan Eye Bank, Illinois Eye Bank), Northwest Lions Eye Bank, San Diego Eye Bank, Sight Society of Northeastern New York (Lions Eye Bank of Albany).

Reprints: Robin L. Gal, MSPH, Cornea Donor Study Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647 (e-mail: rgal@jaeb.org).

© 2005 Lippincott Williams & Wilkins, Inc.