To report the concomitant presentation of keratoconus and macular corneal dystrophy in two cases.
Two siblings with concomitant keratoconus and macular corneal dystrophy are presented. Complete ophthalmologic examination and computerized videokeratography were performed in both patients. Case 1 underwent penetrating keratoplasty in both eyes sequentially; histopathologic examination of excised corneal buttons with special stains was performed. Case 2 was observed.
Both patients manifested typical signs and topographic evidence of keratoconus associated with macular dystrophy. Histopathologic studies in case 1 confirmed the same clinical diagnosis.
To our knowledge, this is the first report of such a concurrence in the English literature and could lead to further studies on the possible pathophysiologic or genetic link between these 2 entities.
From the *Department of Ophthalmology and †Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran; and ‡Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Received for publication March 5, 2003; revision received July 9, 2003; accepted November 7, 2003.
Reprints: Mohammad-Ali Javadi, MD, Labbafinejad Medical Center, Eye Research Center, Pasdaran Avenue/Boostan 9 Street, Tehran 16666, Iran (e-mail: firstname.lastname@example.org).