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Concomitant Keratoconus and Macular Corneal Dystrophy

Javadi, Mohammad-Ali MD*; Rafee’i, Alireza Baradaran MD*; Kamalian, Nasser MD†; Karimian, Farid MD*; Ja’farinasab, Mohammad-Reza MD*; Yazdani, Shahin MD‡

Case Reports

Objective: To report the concomitant presentation of keratoconus and macular corneal dystrophy in two cases.

Methods: Two siblings with concomitant keratoconus and macular corneal dystrophy are presented. Complete ophthalmologic examination and computerized videokeratography were performed in both patients. Case 1 underwent penetrating keratoplasty in both eyes sequentially; histopathologic examination of excised corneal buttons with special stains was performed. Case 2 was observed.

Results: Both patients manifested typical signs and topographic evidence of keratoconus associated with macular dystrophy. Histopathologic studies in case 1 confirmed the same clinical diagnosis.

Conclusion: To our knowledge, this is the first report of such a concurrence in the English literature and could lead to further studies on the possible pathophysiologic or genetic link between these 2 entities.

Author Information

From the *Department of Ophthalmology and †Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran; and ‡Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Received for publication March 5, 2003; revision received July 9, 2003; accepted November 7, 2003.

Reprints: Mohammad-Ali Javadi, MD, Labbafinejad Medical Center, Eye Research Center, Pasdaran Avenue/Boostan 9 Street, Tehran 16666, Iran (e-mail:

© 2004 Lippincott Williams & Wilkins, Inc.