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Utility of Etest in Choosing Appropriate Agents to Treat Fungal Keratitis

Inoue, Tomoyuki M.D.; Inoue, Yoshitsugu M.D.; Asari, Seishi M.T.; Sunada, Atsuko M.T.; Inoue, Yumiko M.D.; Yamamoto, Shuji M.D.; Nishida, Koji M.D.; Maeda, Naoyuki M.D.; Watanabe, Hitoshi M.D.; Shimomura, Yoshikazu M.D.; Tano, Yasuo M.D.

Clinical Sciences

Purpose. To evaluate the utility of Etest in choosing the appropriate treatment of fungal keratitis.

Methods. Etest was used to determine the drug sensitivities of isolates from the eyes of three patients with fungal keratitis, and the clinical outcomes of treatment with selected drugs were evaluated.

Results. In all cases, drug sensitivity demonstrated by Etest accorded with clinical efficacy of the drugs.

Conclusion. The results in these cases suggest that evaluating drug sensitivities with Etest is an efficient means of selecting optimal pharmacotherapy for fungal keratitis.

From the Department of Ophthalmology (T.I., Y.I., Y.I., S.Y., K.N., N.M., H.W., Y.T. ), Osaka University Medical School; Clinical Laboratory (S.A., A.S.), Osaka University, Suita, Osaka; and the Department of Ophthalmology (Y.S.), Kinki University School of Medicine, Sayama Osaka, Japan.

Submitted September 26, 2000.

Revision received February 22, 2001.

Accepted February 24, 2001.

Grants: Supported in part by a Grant-in-Aid for Scientific Research by the Ministry of Education, Science and Culture, Japan, No.12470365, a grant from Osaka Eye Bank, Osaka, Japan.

None of the authors has any proprietary interest in any of the commercial products (Etest or pharmaceutical agents) mentioned in this article.

Address correspondence and reprint requests to Dr. T. Inoue, Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka, Suita Osaka, 565-0871, Japan. E-mail: tinoue@virus.kyoto-u.ac.jp

© 2001 Lippincott Williams & Wilkins, Inc.