Skip Navigation LinksHome > April 1990 - Volume 9 - Issue 2 > Ultrastructural Features of Contact Lens-Induced Deep Cornea...
Long-Term Changes in Corneal Endothelium After Keratoplasty: PDF Only

Ultrastructural Features of Contact Lens-Induced Deep Corneal Neovascularization and Associated Stromal Leukocytes.

Madigan, Michele C. Ph.D., M.D.; Penfold, Philip L. Ph.D., M.D.; Holden, Brien A. Ph.D., M.D.; Billson, Francis A. M.D., F.R.A.C.O.

Collapse Box


Deep stromal vascularization was observed in corneas of four cynomolgus monkeys after extended monocular hy-drogel contact lens wear. Keratocytes and extravascular leukocytes, including macrophages, lymphocytes, and in one case, neutrophils, were associated with the vessels in three monkeys. Vessel regression was observed in some animals, but not when lens wear was continuous. In one animal, neutrophil infiltration of the stroma associated with gross epithelial edema was observed. Involution of neutrophils by apoptosis and phagocytosis of pyknotic cells by macrophages was noted. The present study describes the ultrastructural features of deep corneal vascularization developed during extended contact lens wear and illustrates an association between leukocytes and new vessels.

(C) Lippincott-Raven Publishers.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.