CONTINUUM: Lifelong Learning in Neurology:
doi: 10.1212/01.CON.0000450965.30710.e9
Review Articles

Neurosarcoidosis

Tavee, Jinny O. MD; Stern, Barney J. MD, FAAN

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Abstract

Purpose of Review:

This article provides an update on the evaluation and treatment of neurosarcoidosis.

Recent Findings:

The broad range of clinical manifestations of neurosarcoidosis has recently expanded to include painful small fiber neuropathy. Although definitive diagnosis remains a challenge, fluorodeoxyglucose positron emission tomographic (FDG-PET) scan and high-resolution CT allow for improved detection of systemic sarcoidosis. In addition, endobronchial ultrasound-guided transbronchial needle aspiration provides a less invasive means of tissue confirmation of systemic sarcoidosis than mediastinoscopy. Although not standardized, treatment strategies for neurosarcoidosis now commonly include tumor necrosis factor-α antagonists in combination with corticosteroids and other cytotoxic agents for patients with severe disease.

Summary:

Advances in the diagnosis and management of neurosarcoidosis may benefit the patient and clinician faced with this multifaceted disease.

Copyright © 2014 by the American Academy of Neurology.

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