Outcomes for patients with glioblastoma have improved with the addition of temozolomide (TMZ) chemotherapy to radiation therapy followed by adjuvant TMZ for up to 1 year. Patients often wish to continue chemotherapy after the standard 1-year course. Whether to continue or to stop TMZ is a complex and stressful decision for the patient and family, and the decision should be based on a discussion of the known risks and benefits of each choice.
Address correspondence to Dr Morris D. Groves, 901 West 38th Street, Suite 200, Austin, TX 78705, firstname.lastname@example.org.
Relationship Disclosure: Dr Groves has served as a speaker for Merck and Co., Inc. and has served on the advisory board for Genentech, Inc., and Sanofi-Aventis. Dr Groves received research support for brain tumor research from Angiochem, Celldex, Inc., Enzon Pharmaceuticals, Inc., Genentech, Inc., Merck and Co., Inc., and Reata Pharmaceuticals, Inc. Ms Plummer reports no disclosure.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Groves and Ms Plummer report no disclosure.