Neurodegenerative adult-onset dementias are complex and multifactorial diseases that are most commonly caused by environmental, genetic, or mixed environmental and genetic factors. Regarding the genetic causes, a variety of phenotypes may present. This article reviews several of the genetic risk factors for the most common dementias encountered in neurology. Practical implications of genetic testing and pharmacogenomic considerations for clinical practice are also discussed.
Address correspondence to Dr Richard S. Isaacson, Department of Neurology, University of Miami Miller School of Medicine, Clinical Research Building, 1120 NW 14th Street, CRB 1339, Miami, FL 33136, firstname.lastname@example.org.
Relationship Disclosure: Dr Padilla has nothing to disclose. Dr Isaacson has received personal compensation for speaking engagements from Accera, Novartis, and Pfizer Inc. Dr Isaacson receives student loan payments from the National Institutes of Health Clinical Research Loan Repayment Program.
Unlabeled Use of Products/Investigational Use Disclosure: Drs Padilla and Isaacson have nothing to disclose.