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Neurologic Complications of Hemoglobinopathies

Holmstedt, Christine DO; Adams, Robert J. MS, MD

doi: 10.1212/01.CON.0000394674.90243.a5
Review Articles

ABSTRACT: The hemoglobinopathies, including sickle cell disease and its variants, are genetic abnormalities of hemoglobin. Hemoglobin SS (sickle cell disease) is the most common form of hemoglobin mutation in North America. Complications of hemoglobinopathies are numerous and involve many organ systems, including the nervous system. This article is intended to introduce the reader to the epidemiology, diagnosis, treatment, and prevention of neurologic complications of hemoglobinopathies, focusing specifically on sickle cell disease because of its prevalence.

Address correspondence to Dr Christine Holmstedt, Medical University of South Carolina, 169 Ashley Avenue, Charleston, SC 29425, holmstedt@musc.edu.

Relationship Disclosure: Dr Holmstedt has nothing to disclose. Dr Adams has received personal compensation for consulting and speaking activities from Genentech, Inc.; Novartis; and REACH Call, Inc.; and for legal reviews and expert testimony.

Unlabeled Use of Products/Investigational Use Disclosure: Drs Holmstedt and Adams have nothing to disclose.

© 2011 American Academy of Neurology