No single test to diagnose multiple sclerosis is available, and its cause is unknown. The diagnosis relies on recognition of the clinical patterns of the disease as well as exclusion of other possible mimics. Waxing and waning neurologic deficits that localize to the CNS are the hallmark of the disease in most patients. The diagnosis can be supported by laboratory studies, including MRI of the brain and spinal cord, analysis of CSF, and evoked-potential studies of the visual and somatosensory pathways.
Relationship Disclosure: Dr Cree has received personal compensation for consulting activities from Biogen Idec, Elan Corporation, Sanofi-Aventis, and Teva Neuroscience and has received research support from BioMS Medical Corporation; EMD Serono, Inc; and Genentech, Inc. Dr Cree's compensation and/or research work has been funded entirely or in part by grants to his university from a governmental organization and a for-profit organization.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Cree clearly indicates the off-label use of products when discussed.