Many effective antiepileptic drugs (AEDs) are currently available. These are generally subdivided into the first-generation AEDs (phenytoin, carbamazepine, phenobarbital, primidone, valproate, ethosuximide, and the benzodiazepines), and the second-generation AEDs (felbamate, gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, zonisamide, and pregabalin). Selection of the ideal drug for each individual patient should be based on a number of factors, including cost, spectrum of activity, potential for dose-related and serious side effects, drug interactions, and others. Special consideration must be given to populations such as women, older adults, and newly diagnosed patients. When all factors are taken into consideration, most patients can find an effective and well-tolerated drug.