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INFLAMMATORY MYOPATHIES

Amato, Anthony A.; Greenberg, Steven A.

CONTINUUM: Lifelong Learning in Neurology: June 2006 - Volume 12 - Issue 3, Muscle Diseases - pp 140-168
doi: 10.1212/01.CON.0000290466.34703.26
Article

The three major categories of idiopathic inflammatory myopathy are dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). These disorders are clinically, histologically, and pathogenically distinct. DM is a humorally mediated microangiopathy, while PM is a T-cell-mediated disorder directed against muscle fibers. The pathogenesis of IBM is unknown. DM and PM are responsive to immunosuppressive therapy, in contrast to IBM, which is generally refractory to therapy. Prospective, double-blind, placebo-controlled trials are necessary to determine prognostic features and the best treatment options for the different inflammatory myopathies.

© 2006 American Academy of Neurology
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