Skip Navigation LinksHome > September 2011 - Volume 24 - Issue 3 > APOE ε4 Is Associated With Exacerbation of Cognitive Decline...
Cognitive & Behavioral Neurology:
doi: 10.1097/WNN.0b013e31823380b5
Original Studies

APOE ε4 Is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis

Shi, Jiong MD, PhD*,†; Tu, Jiang-long MD*; Gale, Shawn D. PhD; Baxter, Leslie PhD; Vollmer, Timothy L. MD§; Campagnolo, Denise I. MD*; Tyry, Tuula M. PhD*; Zhuang, Yi MD; Kuniyoshi, Sandra M. MD, PhD

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Background: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) ε4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE ε4 status exacerbates progression of cognitive deficits in MS.

Methods: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits.

Results: The APOE ε4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE ε4 carriers (P=0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype.

Conclusions: APOE ε4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE ε4 carrier status predicts cognitive decline in verbal learning and memory.

© 2011 Lippincott Williams & Wilkins, Inc.


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