Background: Alzheimer disease (AD) is a progressive, fatal neurodegenerative condition.
Objective: We tested the hypothesis that eradication of Helicobacter pylori infection (Hp-I) could improve survival in a Greek cohort of AD patients, in a 5-year follow-up.
Method: Forty-six patients diagnosed with probable AD were enrolled in the analysis. Study population was classified into 3 groups: patients for whom Hp eradication treatment was successful; those for whom eradication of Hp had failed, they refused, and/or were noncompliant with eradication therapy; and those who were Hp negative at baseline. Cox proportional hazards model was built with all-cause mortality as the dichotomous outcome.
Results: During the 5-year follow-up [47.19±15.11 mo (range 12 to 60)], overall 21 patients died and 25 patients remained alive. Patients who died were older and exhibited lower mean MMSE score compared with the patients still alive. Successful eradication of Hp-I was associated with a significantly lower mortality risk [HR (95% CI)=0.287 (0.114-0.725), P=0.008]. The results were similar in adjusted and unadjusted models, for age and MMSE at baseline.
Conclusion: Hp eradication regimen in AD patients is associated with a higher 5-year survival rate.
*Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital
†Second Neurological Clinic, “AHEPA” General Hospital, Aristotle University of Thessaloniki
‡Neurological Clinic, “Papageorgiou” General Hospital, Thessaloniki, Greece
Reprints: Jannis Kountouras, MD, PhD, Department of Gastroenterology, Aristotle University of Thessaloniki, Ippokration Hospital 8 Fanariou Street, Byzantio, Thessaloniki, 551 33, Macedonia, Greece (e-mail: email@example.com).
Received for publication November 20, 2009; accepted March 14, 2010