Skip Navigation LinksHome > September 2010 - Volume 23 - Issue 3 > Dementia Developing in Late-onset and Treatment-refractory O...
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Cognitive & Behavioral Neurology:
doi: 10.1097/WNN.0b013e3181e61ce0
Case Report

Dementia Developing in Late-onset and Treatment-refractory Obsessive-compulsive Disorder

Frydman, Ilana MD*; Ferreira-Garcia, Rafael MD*; Borges, Manuela C. PhD*; Velakoulis, Dennis MBBS, FRANZCP; Walterfang, Mark MBBS, FRANZCP; Fontenelle, Leonardo F. MD, PhD* † ‡

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Background: Although several studies have been conducted in an attempt to characterize the phenotype and underlying pathophysiology of individuals with early-onset obsessive-compulsive disorder (OCD), the literature on patients who develop OCD later in life remains sparse.

Objective: To describe clinical outcomes in the 7-year follow-up of a patient with late-onset OCD.

Method: Single case report.

Results: A 64-year-old woman exhibiting a 7-year history of treatment-refractory late-onset OCD developed significant cognitive deterioration. We suggest that the association between late-onset treatment refractory OCD and dementia may stem from at least 3 different scenarios. First, dementia may be an inexorable end-point of some forms of malignant, primary, and late-onset obsessional illness. Second, late-onset OCD and dementia may result from a common pathophysiologic basis, such as in fronto-temporal dementia. Finally, the association between both conditions may result by the interaction between vulnerability toward OCD-type symptoms and the nonspecific effects of a neurodegenerative process. In our case, although subclinical OCD was likely to be “unmasked” by cognitive decline and/or bilateral caudate vascular lesions, ensuing cognitive deterioration could be ascribed to development of Alzheimer dementia.

Conclusion: Our observation suggests that treatment refractoriness in an individual with late-onset OCD may indicate underlining organicity.

© 2010 Lippincott Williams & Wilkins, Inc.


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