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Cognitive & Behavioral Neurology:
doi: 10.1097/WNN.0b013e3181cfb52a
Original Studies

Progressive Ventricular Expansion in Chronic Poor-outcome Schizophrenia

Mitelman, Serge A. MD*; Canfield, Emily L. MA*; Brickman, Adam M. PhD; Shihabuddin, Lina MD*; Hazlett, Erin A. PhD*; Buchsbaum, Monte S. MD

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Objective: To compare progressive changes in lateral ventricular size in chronic schizophrenia patients with good and poor outcomes.

Background: Several longitudinal studies associated excessive ventricular enlargement with poor outcome early in the course of schizophrenia. Changes in its chronic phase have not been as well ascertained.

Methods: We used MRI to evaluate progression of the lateral ventricular size in 49 chronic schizophrenia patients (26 with poor outcome, 23 with good outcome) and 16 healthy comparison participants, scanned twice 4 years apart.

Results: In comparison with healthy participants, schizophrenia patients displayed significantly enlarged body, and anterior and posterior horns of the lateral ventricles at baseline and follow-up, but no between-group differences in their longitudinal expansion were observed. Progressive enlargement of the posterior horn in the poor-outcome (Kraepelinian) group, however, was more pronounced than in schizophrenia patients with good outcome.

Conclusions: Excessive ventricular enlargement in the chronic phase of schizophrenia may be specifically associated with poor functional outcome of the illness.

© 2010 Lippincott Williams & Wilkins, Inc.


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