Objective: The aims of this study wereto assess frontal dysfunction in Turkish patients with idiopathic Parkinson disease (PD) by using frontal assessment battery (FAB), and to determine the relationship among FAB scores and education, Mini-Mental State Examination (MMSE), and severity of the disease.
Background: Cognitive impairment in patients with PD mainly involves executive dysfunction. Executive dysfunction is mainly related to the frontal lobes and their connections with the thalamus and basal ganglia. FAB is an easily applicable and valid test to examine frontal functions.
Method: Forty patients diagnosed with PD and 52 healthy controls were included in the study. Age, sex, disease duration, and Unified Parkinson's Disease Rating Scale scores were noted. FAB and MMSE were administered to all participants. Both groups were compared according to FAB scores, MMSE, age, and education.
Results: FAB scores were significantly lower in patients with PD (P=0.00) than in healthy controls. In patients with PD, FAB scores were solely correlated with MMSE. In the subgroup analysis, the performance of patients with PD was worse than the healthy participants on similarities and fluency tasks.
Conclusions: FAB scores are lower in Turkish patients with PD than in the healthy participants, and could be used for the evaluation of subtle cognitive deficits in these patients.
Sisli Etfal Education and Research Hospital, Istanbul, Turkey
Reprints: Gulay Kenangil, MD, Sisli Etfal Education and Research Hospital, Yeni Camlıca mah, Duman sok, No: 50, 7000-A 320 Atasehir, Istanbul, Turkey (e-mail: firstname.lastname@example.org).
Received for publication February 25, 2009
accepted October 11, 2009