Institutional members access full text with Ovid®

When the Amnestic Mild Cognitive Impairment Disappears: Characterisation of the Memory Profile

Perri, Roberta MD, PhD*; Carlesimo, Giovanni A. MD, PhD* †; Serra, Laura PsyD, PhD*; Caltagirone, Carlo MD* †; and the Early Diagnosis Group of the Italian Interdisciplinary Network on Alzheimer's Disease

Cognitive & Behavioral Neurology: June 2009 - Volume 22 - Issue 2 - pp 109-116
doi: 10.1097/WNN.0b013e3181a7225c
Original Studies

Background/Objectives: Subjects affected by mild cognitive impairment (MCI) may improve during the observation period. This is the first study investigating qualitative features of memory deficits in subjects affected by reversible MCI [reversible cognitive impairment (RCI)].

Methods: Baseline cognitive and memory performances of 18 subjects affected by amnestic MCI who had normalized cognitive performances at follow-ups were compared with those of 76 amnestic MCI subjects who still showed impaired cognitive performances at the 24-month follow-up (MCI) and with those of a group of 87 matched control subjects (normal controls).

Results: Compared with normal controls the memory deficit in the MCI group affected all aspects of explicit long-term memory functioning; in the RCI group, instead, the memory deficit only affected the free recall of verbal material, particularly when the encoding could be improved by the use of semantic strategies.

Conclusions: These results are consistent with the view that the memory deficit in the MCI group is due to a very early degenerative pathology; in the RCI group, instead, a transitory reduction of processing resources, resulting a poor encoding of incoming material, is likely at the origin of the reversible memory disorder.

*Foundation IRCCS Santa Lucia

University of Rome “Tor Vergata,” Rome, Italy

Reprints: Roberta Perri, MD, PhD, Fondazione IRCCS Santa Lucia, Via Ardeatina 306, Rome 00179, Italy (e-mail: r.perri@hsantalucia.it).

Received for publication May 8, 2008; Accepted March 4, 2009

Early Diagnosis Group of the Italian Interdisciplinary Network on Alzheimer Disease. Members and Centres who participated to the study: Fondazione Don Gnocchi, Milano: M. Alberoni; Ospedale S. Gerardo, Monza: I. Appollonio; INRCA—C. da Mossa, Ascoli Piceno: S. Bonaiuto; Ospedale Niguarda, Milano: G. Bottini; Università di Parma, Parma: P. Caffarra; Università Tor Vergata and Fondazione Santa Lucia, Roma: C. Caltagirone; II Università di Napoli, Napoli, S. Carlomagno; Ospedale S. Salvatore, L'Aquila: A. Carolei and P. Sucapane; Ospedale Sant'Anna, Ferrara: P. De Bastiani; Università di Milano, Milano: M. Di Luca; Clinica Santa Maria HSR, Castellanza: M. Franceschi; Ospedale Ca' Foncello, Treviso: M. Gallucci; Azienda Ospedaliera di Verona, Verona: G. Gambina; Arcispedale Santa Maria Nuova, Reggio Emilia: E. Ghidoni; Ospedale C. Besta, Milano: F. Girotti; Università La Sapienza, Roma, F. Giubilei; Ospedale degli Infermi di Rimini, Rimini: S. Lorusso; IRCCS Fondazione Maugeri, Veruno: C. Marchetti; Università di Palermo, Palermo: R. Monastero; Università La Sapienza, Roma, C. Mina; Università di Brescia, Brescia: A. Padovani; Azienda Ospedaliera Sant' Antonio Abate, Gallarate: M. Perini; Centro Regionale Alzheimer—Passirana di Rho, Milano: C. Pettenati; Università di Sassari, Sassari: M.R. Piras; Università degli Studi, Ancona: L. Provinciali; Policlinico Universitario, Messina, A. Quartarone and A. Graceffa; Università di Perugia, Perugia: U. Senin; Ospedale Santa Chiara, Pisa: G. Tognoni; ASL 15, Cuneo: P. Zagnoni; Bracco-Spa, Milano: E. Grossi and R. Savarè.

© 2009 Lippincott Williams & Wilkins, Inc.