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Cognitive & Behavioral Neurology:
doi: 10.1097/WNN.0b013e31817d74d0
Original Studies

Chronic Information-processing Changes in Individuals With a First-ever Clinical Lacunar Syndrome

Anderson, Jacqueline F. I. PhD*; Saling, Michael M. PhD*; Donnan, Geoffrey A. MD

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Abstract

Objective: The aim of this study was to examine whether chronic cognitive changes occur after a first-ever single clinical lacunar syndrome.

Background: Patients who have been diagnosed with a first-ever single clinical lacunar syndrome, on the basis of clinical rather than radiologic criteria, perform normally on general clinical neuropsychologic measures.

Method: We examined information-processing abilities in 17 first-ever lacunar syndrome participants [lacunar anterior circulation infarct (LACI)], using 2 experimental tasks of information processing.

Results: At a group level, LACI participants were significantly impaired relative to stroke-free controls. Specifically, LACI participants had a reduced ability to process information under conditions of increasing attentional demand; this deficit was not caused by a fundamental impairment in speed of information processing.

Conclusions: The current findings represent the first evidence of chronically impaired cognition in individuals who have suffered a single clinical lacunar syndrome event, but have no history of other clinical stroke.

© 2008 Lippincott Williams & Wilkins, Inc.

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