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Treatment of hypertension in renal transplant recipients

Tylicki, Leszeka; Habicht, Antjeb; Watschinger, Brunob; Hörl, Walter H.b

Current Opinion in Urology:
Renal medicine and renal transplantation
Abstract

Purpose of review: Hypertension is very common in renal transplant recipients and is a significant risk factor for mortality from cardiovascular diseases and for development of graft dysfunction.

Recent findings: Recent guidelines for the treatment of hypertension (Joint National Committee on Prevention, Detection, and Treatment of High Blood Pressure VI Report and World Health Organization Guidelines) do not directly address post-transplant hypertension. Specific recommendations for the drug treatment of hypertension in renal allograft recipients have not been given in the Clinical Practice Guidelines of the American Society of Transplantation or those of the European Renal Association.

Summary: The present paper summarizes some important aspects of post-transplant hypertension and discusses potential treatment strategies aimed at reducing blood pressure and thus improving patient and allograft survival.

Author Information

aDepartment of Internal Medicine, Nephrology and Transplantology, Medical University of Gdansk, Gdansk, Poland, and bDivision of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria

Correspondence to Leszek Tylicki MD, PhD, Department of Nephrology, Medical University of Gdansk, ul. Debinki 7, 80-211 Gdansk, Poland Tel./fax: +48 58 346 1186; e-mail: leszek.tylicki@wp.pl

Abbreviations ACEI: angiotensin converting enzyme inhibitor ARA: angiotensin II type 1 receptor antagonist CCB: calcium channel blocker RAS: renin-angiotensin system RTR: renal transplant recipient TGF: transforming growth factor

© 2003 Lippincott Williams & Wilkins, Inc.