Current Opinion in Urology

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Current Opinion in Urology:
Renal medicine and renal transplantation

Genetic variability and transplantation

Marder, Brad; Schröppel, Bernd; Murphy, Barbara

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Purpose of review: The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications.

Recent findings: Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation.

Summary: These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.

© 2003 Lippincott Williams & Wilkins, Inc.


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