Skip Navigation LinksHome > April 2013 - Volume 18 - Issue 2 > Organogenesis for kidney regeneration
Current Opinion in Organ Transplantation:
doi: 10.1097/MOT.0b013e32835f070d
ORGANOGENESIS AND ORGAN REGENERATION AND REPAIR AFTER TRANSPLANTATION: Edited by Jeffrey L. Platt

Organogenesis for kidney regeneration

Yokote, Shinya; Yokoo, Takashi

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Abstract

Purpose of review: The kidney has an elaborate and complicated structure comprising several cell types. Damage or destruction of the kidney thus necessitates reconstruction of all the component cell types to regenerate a functional three-dimensional renal structure. Therefore, despite all the recent advances in our understanding and technical approaches to stem cell and developmental biology, the anatomical complexity of the renal system makes de-novo kidney regeneration the most difficult challenge for organ regenerative therapy.

Recent findings: To build a transplantable neo-kidney, some investigators propose using organogenesis. We suggest the metanephros of the developing kidney and blastocyst complementation can potentially generate a whole kidney with the required three-dimensional structure and renal function to produce urine and erythropoietin. In addition, some researchers are investigating the in-vitro differentiation of pluripotent stem cells into mature renal cells for in-vivo use.

Summary: We review the current challenges to making a transplantable neo-kidney using stem cells.

© 2013 Lippincott Williams & Wilkins, Inc.

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