Skip Navigation LinksHome > May 2010 - Volume 22 - Issue 3 > Interferon therapy in rheumatic diseases: state-of-the-art 2...
Current Opinion in Rheumatology:
doi: 10.1097/BOR.0b013e3283368099
Clinical therapeutics: Edited by Gerd Burmester and Thomas Dorner

Interferon therapy in rheumatic diseases: state-of-the-art 2010

Kötter, Inaa; Hamuryudan, Vedatb; Öztürk, Zafer Ec; Yazici, Hasanb

Collapse Box


Purpose of review: Interferons are natural glycoproteins that have antiviral, antiproliferative and immune regulatory functions. They are not only involved in the pathogenesis of certain autoimmune conditions but are also useful in the treatment of some rheumatologic disorders, notably Behçet's syndrome.

Recent findings: Interferon alpha (IFNα) has been recommended for severe eye involvement in Behçet's syndrome, especially when there is a significant drop in visual acuity and/or retinal involvement. It can induce a high rate of complete remission that may also persist after its discontinuation. When given early at the beginning, interferon might be effective in ameliorating the attacks of familial Mediterranean fever resistant to colchicine treatment. The combination of PEGylated IFNα with ribavirin and rituximab emerges as a novel and promising treatment providing complete clinical response and viral clearance in hepatitis C virus-associated mixed cryoglobulinemia. Limited data also suggest that interferon may induce remissions in Churg-Strauss patients who fail to respond to conventional immunosuppressive treatment.

Summary: Among several rheumatologic diseases, IFNα has found more widespread use in Behçet's syndrome and hepatitis C virus-associated mixed cryoglobulinemia despite a paucity of formal studies. Patients should be carefully monitored for the frequent and dose-dependent adverse effects.

© 2010 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.