Skip Navigation LinksHome > January 2014 - Volume 20 - Issue 1 > Systems biology approach for subtyping asthma; where do we s...
Current Opinion in Pulmonary Medicine:
doi: 10.1097/MCP.0000000000000004
ASTHMA: Edited by Nicola A. Hanania and Zuzana Diamant

Systems biology approach for subtyping asthma; where do we stand now?

Kaminsky, David A.

Collapse Box

Abstract

Purpose of review

The purpose of this review is to discuss the present systems biology approach to asthma and how it is helping to define asthma subtypes. Although the general concept of systems biology will be discussed, the article will focus on recent developments in the field related to asthma.

Recent findings

The most recent work in systems biology and asthma has occurred in the area of genomics (e.g., pharmacogenomics and gene–environment interactions), protein interaction networks [e.g., interleukin (IL)-33/IL-1 receptor-like 1 signaling], cluster analysis of asthma patients (e.g., application of severe asthma research program clusters to a general urban asthma population), and multiscale approaches to asthma encompassing data from the molecule to whole organ (e.g., modeling of airways hyperresponsiveness).

Summary

The results of recent work in this area have led to new insight into gene–cytokine and protein–protein networks involved in asthma, a better determination of key clinical factors associated with asthma subtypes, and the beginning of sophisticated multiscale approaches to modeling, understanding and predicting the behavior of the asthmatic lung.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.