Current Opinion in Pediatrics

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Current Opinion in Pediatrics:
October 2002 - Volume 14 - Issue 5 - pp 593-600
Gastroenterology and nutrition

Nonalcoholic fatty liver disease (NAFLD) in children

Sathya, Pushpa MD; Martin, Steven MD; Alvarez, Fernando MD

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is common in obese children and is a growing problem, given the increase in prevalence of obesity. NAFLD is also associated with diabetes, insulin resistance, hypercholesterolemia, and hypertriglyceridemia. Although mostly benign, some children with NAFLD develop fibrosis and cirrhosis, which necessitates close monitoring. Chronically elevated plasma liver enzyme levels is the most frequent finding. Ultrasound (US) examination allows confirmation of the diagnosis and it is useful for the follow-up. Gradual and sustained weight reduction is a management option that is worth trying initially. Other modalities of management, although interesting, await evidence as well as information on long-term benefits and effects. Sustained increase of transaminases despite weight reduction is a cause for concern and may require a liver biopsy both to assess severity of liver damage and for prognostic purposes.

© 2002 Lippincott Williams & Wilkins, Inc.

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