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Management of drug-induced hyperthermia>

Halloran, Lindara L; Bernard, David W

Current Opinion in Pediatrics: April 2004 - Volume 16 - Issue 2 - pp 211-215
Therapeutics and toxicology

Purpose of review: To review the current literature describing drug-induced hyperthermia and its treatment. Specifically, five syndromes will be discussed: malignant hyperthermia, neuroleptic malignant syndrome, anticholinergic poisoning, sympathomimetic poisoning, and serotonin syndrome.

Recent findings: The most recent findings in the literature are the recognition of previously undescribed drugs or drug combinations that have lead to hyperthermia. Recent literature also attests to the potential morbidity and mortality of drug-induced hyperthermia.

Summary: Although the recognition of causative agents is increasing, the treatment of drug-induced hyperthermia remains unchanged and continues to be primarily supportive.

Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama, USA

Correspondence to Lindara Halloran, Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama School of Medicine, 1600 7th Avenue South, Midtown Center Suite 205, Birmingham, AL 35233, USA

Tel: 205 939 6040; fax: 205 975 4623; e-mail: lhalloran@peds.uab.edu

© 2004 Lippincott Williams & Wilkins, Inc.