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Current Opinion in Otolaryngology & Head & Neck Surgery:
doi: 10.1097/MOO.0000000000000043
ALLERGY: Edited by Sandra Y. Lin

Current understanding of allergic fungal rhinosinusitis and treatment implications

Plonk, Drew P.; Luong, Amber

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Abstract

Purpose of review

The pathophysiology of allergic fungal rhinosinusitis (AFRS) is not fully understood and is in constant evolution. Although initial theories favored an immunoglobulin E-mediated immune response to fungal antigens as having a primary role in the immunopathologic process of AFRS, the purpose of this review is to highlight recent studies that suggest a more complex, epithelial cell-driven immune response being central to the pathophysiology of the disease. Treatment implications are considered.

Recent findings

Recent studies demonstrate a central role of cytokines derived from respiratory epithelial cells, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin, in the orchestration of both innate and adaptive T helper 2 immune responses that are important components of the immunopathology of chronic rhinosinusitis with nasal polyposis and AFRS. In addition, the robust Th2 adaptive response may be mediated by both fungal antigens and Staphylococcus aureus superantigens.

Summary

Given the evolving understanding of AFRS pathophysiology, management continues to maintain a broad focus on minimizing the burden of the inflammatory trigger(s) and suppressing the inflammatory cascade. This is primarily accomplished through surgery and corticosteroid therapy. Immunotherapy, antimicrobial therapy, and other immunomodulatory medications may help mediate the disease process as well.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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