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Sublingual immunotherapy and quality of life

Laury, Adrienne M.a; Schlosser, Rodney J.b; Wise, Sarah K.a

Current Opinion in Otolaryngology & Head & Neck Surgery:
doi: 10.1097/MOO.0b013e32835fcb22
ALLERGY: Edited by Sandra Lin

Purpose of review: Sublingual immunotherapy (SLIT) has been shown to be a new and promising treatment for people with various allergic syndromes. Several studies have examined its efficacy. However, significantly fewer investigations have explored its specific impact on the patient's quality of life (QOL).

Recent findings: SLIT has an excellent safety profile, superior in many ways to subcutaneous immunotherapy (SCIT). Additionally, SLIT significantly decreases the use of allergy medications, as well as decreasing the money spent on allergy symptom control. Finally, SLIT has been shown to improve the patient's QOL when compared to placebo or even second-generation antihistamines.

Summary: Increasing data support the use of SLIT as a well tolerated, cost-effective, and time-efficient modality for the treatment of multiple allergic syndromes. However, additional studies are needed, particularly QOL studies which compare SLIT to the FDA-approved SCIT.

Author Information

aDepartment of Otolaryngology – Head and Neck Surgery, Emory University, Atlanta, Georgia

bDepartment of Otolaryngology – Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA

Correspondence to Sarah K. Wise, MD, MSCR, Emory University, 550 Peachtree Street, MOT 9th Floor, Atlanta, GA 30308, USA. Tel: +1 404 778 3381; fax: +1 404 686 4540; e-mail:

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