Skip Navigation LinksHome > April 2013 - Volume 21 - Issue 2 > Tracheal replacement for primary tracheal cancer
Current Opinion in Otolaryngology & Head & Neck Surgery:
doi: 10.1097/MOO.0b013e32835e212b
HEAD AND NECK ONCOLOGY: Edited by Piero Nicolai and Cesare Piazza

Tracheal replacement for primary tracheal cancer

Haag, Johannes C.; Jungebluth, Philipp; Macchiarini, Paolo

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Abstract

Purpose of review: To summarize the so far applied clinical methods of tracheal replacement, comparing pros and cons of conventional and tissue-engineered approaches.

Recent findings: Several strategies have been most recently described to replace the trachea-like aortic homografts, allotransplantation, and tissue engineering. Allotransplantation requires lifelong immunosuppression and this may be ethically questioned being not a lifesaving procedure. Tissue-engineered tracheal transplantation has been clinically applied using biological or bioartificial tubular or bifurcated scaffolds reseeded with mesenchymal stromal cells, and bioactive molecules boosting regeneration and promoting neovascularization.

Summary: Tracheal tissue engineering may be a promising alternative to conventional allotransplantation in adults and children. Different methods have been developed and are currently under active clinical investigation, and await long-term results.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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