To discuss the unique properties of the olfactory epithelium and the potential use of olfactory epithelial grafts to restore olfactory function.
Sensory neurons in the olfactory epithelium undergo continuous regeneration, grow new axons, and reestablish connections with the olfactory bulb throughout life. When transplanted into different regions of the brain, olfactory epithelial graft cells retain their morphological and regenerative properties. Olfactory cells within the grafts grow axons that enter into the surrounding brain tissue. Recent studies have shown that the olfactory epithelium can be grafted directly to the olfactory bulb.
The olfactory epithelium has a remarkable capacity to continuously generate new sensory neurons and survives grafting into different regions of the brain. A review of the literature and the future use of olfactory grafts as a potential method to restore olfactory function is discussed.
aDepartments of Physiology and Biophysics, and Otolaryngology-Head & Neck Surgery, VCU School of Medicine, Richmond, Virginia, USA
bDepartment of Otorhinolaryngology-Head & Neck Surgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
Correspondence to Richard M. Costanzo, PhD, Department of Physiology and Biophysics, VCU School of Medicine, 1101 East Marshall Street, Richmond, VA 23298-0551, USA Tel: +1 804 828 4774; fax: +1 804 828 7382; e-mail: email@example.com