IgE-mediated food allergyCalhoun, Karen H; Schofield, Minka LCurrent Opinion in Otolaryngology & Head and Neck Surgery: June 2010 - Volume 18 - Issue 3 - p 182–186 doi: 10.1097/MOO.0b013e328339530e Allergy: Edited by Berrylin J. Ferguson Abstract Author Information Purpose The increasing incidence of IgE-mediated food allergy has led to further study of this atopic disease. Recent findings Food allergy represents a failure to attain oral tolerance marked by a pronounced Th2 versus T-regulatory cell response. The gold standard for the diagnosis of food allergy is a double-blind, placebo-controlled food challenge. Evidence supports breastfeeding to prevent certain atopic diseases but there is no support for delayed food introduction or maternal diet restrictions during pregnancy or lactation. There is no cure for food allergies. The mainstay of therapy is avoidance and management of severe reactions with self-injectable epinephrine. Other promising therapies include oral immunotherapy and sublingual immunotherapy. Summary The mechanism of IgE-mediated food allergy is better understood but further research is needed to prevent and treat food allergies. Department of Otolaryngology - Head and Neck Surgery, Ohio State University Medical Center, Ohio, USA Correspondence to Karen H. Calhoun, MD, Professor, Department of Otolaryngology Head and Neck Surgery, Ohio State University Medical Center, 915 Olentangy River Road, Columbus, Ohio 43212, USA Tel: +1 614 366 1825; fax: +1 614 293 9698; e-mail: Karen.Calhoun@osumc.edu © 2010 Lippincott Williams & Wilkins, Inc.