High-intensity focused ultrasound ablation: a new strategy to manage primary bone tumorsChen, Wenzhi; Zhou, KunCurrent Opinion in Orthopaedics: December 2005 - Volume 16 - Issue 6 - pp 494-500 Tumors Abstract Author Information Purpose of review: This review attempts to summarize the current status of the experimental and clinical studies using high intensity focused ultrasound ablation to manage malignant primary bone tumors. Recent findings: A novel extracorporeal and noninvasive strategy for managing solid tumors compared with surgical removal or other minimally invasive modalities, high intensity focused ultrasound ablation has been used mostly in China to treat human patients. By using imaging techniques like computed tomography and magnetic resonance images, as well as pathologic examination, efficacy of this strategy for the treatment of primary bone tumors were evaluated and compared. Results have shown good potentiality of high intensity focused ultrasound ablation in complete tumor ablation and improvement of secondary host anti-tumor immunity. Summary: Although further investigations on long-term follow-up results after high intensity focused ultrasound ablation are still needed, this modality may be one of the most promising treatment technologies for bone tumors and limb salvage in the future. Clinical Center for Tumour Therapy of the 2nd Affiliated Hospital, and Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing, China Correspondence to Dr Wenzhi Chen, Department of Biomedical Engineering, Chongqing University of Medical Sciences, 1 Yixueyuan Rd., Yuzhong Dist., Chongqing 400016, China Tel: +86 23 68636364; fax: +86 23 68610718; e-mail: firstname.lastname@example.org © 2005 Lippincott Williams & Wilkins, Inc.