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Fungal keratitis

Srinivasan, M

Current Opinion in Ophthalmology:
Corneal and external disorders

Purpose of review:Throughout the world, fungal keratitis is a leading cause of ocular morbidity. The purpose of this review is to discuss the recently published literature in relation to the epidemiology, etiology, diagnosis, and therapy of fungal keratitis.

Recent findings:Globally, the incidence of keratomycoses and systemic mycoses is rising. Current therapies are often ineffective. Ongoing research toward rapid diagnosis and specific drug therapy could minimize the morbidity caused by this preventable disease. New antifungal drugs, including voriconazole, have been applied recently for the treatment of keratomycosis.

Summary:The incidence of fungal keratitis is on the rise in the densely populated continents of Asia and Africa. Filamentous fungi are the most frequently reported pathogens. Polyene antifungal antibiotics, the first-line therapy in fungal keratitis, are not effective in severe keratomycosis. Imidazole derivatives such as voriconazole and echinocandin may be the better choice in the future.

Aravind Eye Care System, Tamil Nadu, India

Supported by Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India.

Correspondence to M. Srinivasan, Cornea Service, Aravind Eye Care System, 1 Anna Nagar, Madurai, Tamil Nadu, India 625 020

Tel: 91 0452 5356100; fax: 91 0452 2530984; e-mail: m.srinivasan@aravind.org

© 2004 Lippincott Williams & Wilkins, Inc.