Skip Navigation LinksHome > September 2011 - Volume 23 - Issue 5 > Bortezomib-induced Epstein–Barr virus and Kaposi sarcoma her...
Current Opinion in Oncology:
doi: 10.1097/CCO.0b013e3283499c37
Cancer in AIDS: Edited by Ronald Mitsuyasu

Bortezomib-induced Epstein–Barr virus and Kaposi sarcoma herpesvirus lytic gene expression: oncolytic strategies

Reid, Erin G.

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Abstract

Purpose of review: Gamma herpesviruses (GHVs) are responsible for a substantial proportion of virus-associated human cancers, particularly in immunocompromised individuals. Methods that employ lytic activation of viruses latently infecting tumors represent a novel strategy of antineoplastic therapy.

Recent findings: The proteasome inhibitor, bortezomib, has been shown to be a potent activator of GHV lytic cycle and has demonstrated activity in case reports of GHV-related malignancies. Although initial reports implicated the inhibition of the NF-κB pathway, more recent studies identify alternative pathways responsible for bortezomib-mediated lytic induction of GHVs and activity against the malignancies that harbor them.

Summary: Further exploration of proteasome inhibition as an oncolytic strategy is warranted and will require clinical/translational trials to determine whether lytic induction of GHVs correlates with clinical response to bortezomib, and, if so, to optimize this oncolytic strategy.

© 2011 Lippincott Williams & Wilkins, Inc.

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