Skip Navigation LinksHome > May 2010 - Volume 22 - Issue 3 > Advances in the systemic treatment of head and neck cancers
Current Opinion in Oncology:
doi: 10.1097/CCO.0b013e3283376e15
Head and neck: Edited by Ahmad Awada

Advances in the systemic treatment of head and neck cancers

Specenier, Pol; Vermorken, Jan B

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Abstract

Purpose of review: To summarize the recent literature on the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck.

Recent findings: Multiple targeted therapies and novel combinations of chemotherapeutic agents were tested.

Summary: In a large randomized phase III trial, the addition of cetuximab to platin-based chemotherapy led to a significant prolongation of overall survival. The combination of cetuximab and platin/5-fluorouracil should be considered the current standard first-line regimen. In contrast, the results with oral tyrosine kinase inhibitors and other targeted agents have been disappointing thus far.

© 2010 Lippincott Williams & Wilkins, Inc.

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