Skip Navigation LinksHome > October 2014 - Volume 26 - Issue 5 > Precocious puberty
Current Opinion in Obstetrics & Gynecology:
doi: 10.1097/GCO.0000000000000099
ADOLESCENT AND PEDIATRIC GYNECOLOGY: Edited by Paula J. Adams Hillard

Precocious puberty

Neely, E. Kirk; Crossen, Stephanie S.

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Abstract

Purpose of review

Precocious puberty continues to elicit great interest and concern among medical practitioners, as well as the public.

Recent findings

Studies have elucidated neural regulation of puberty by kisspeptin, neurokinin B, and other factors. Cohort studies from the North America and Europe suggest that the age of thelarche may be earlier than determined 2 decades ago, and menarche may be slightly earlier, but the causes are unclear. Long-term outcomes of gonadotropin-releasing hormone analog therapy demonstrate increases in final height in the youngest treated patients, with no apparent adverse bone or reproductive consequences.

Summary

Although the appropriate threshold age of onset of central puberty remains uncertain, gonadotropin-releasing hormone analog therapy is well tolerated and effective in suppressing luteinizing hormone pulses and ovarian activity.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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