Skip Navigation LinksHome > August 2014 - Volume 26 - Issue 4 > Selective progesterone receptor modulators
Current Opinion in Obstetrics & Gynecology:
doi: 10.1097/GCO.0000000000000082
REPRODUCTIVE ENDOCRINOLOGY: Edited by David L. Olive

Selective progesterone receptor modulators

Whitaker, Lucy H.R.; Williams, Alistair R.W.; Critchley, Hilary O.D.

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Abstract

Purpose of review

Review of recent data from clinical trials and descriptions of endometrial morphology with administration of selective progesterone receptor modulators (SPRMs).

Recent findings

Recent reports concerning administration of SPRMs, specifically the efficacy of ulipristal acetate in reducing fibroid size and rapid control of menstrual blood loss, have renewed clinical interest in this class of compound. Histological data from studies with SPRMs report that this class of drugs is associated with progesterone receptor modulator-associated endometrial changes. Data on mechanisms of action are lacking. The antagonistic progesterone effect of SPRMs has shown promising results in animal studies with endometriosis. Sex steroid receptor effects of PRMs outside the reproductive tract raise the potential for use in neurology and oncology, and although there are several randomized trials in these areas, there are limited small studies published to date.

Summary

The SPRM ulipristal acetate is an effective treatment for preoperative treatment of fibroids and a reliable emergency contraceptive. This class of compounds holds the potential for long-term effective medical management of fibroids and may have utility in the management of other sex steroid-dependent conditions.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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