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Current Opinion in Obstetrics & Gynecology:
doi: 10.1097/GCO.0000000000000042
SPECIAL COMMENTARY: Edited by Anne Rodriguez

Chemotherapy in the treatment of metastatic, persistent, and recurrent cervical cancer

Eskander, Ramez N.; Tewari, Krishnansu S.

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Abstract

Purpose of review: Patients with cervical cancer represent a vulnerable population with limited chemotherapeutic options. This year, two large trials focusing on detection/screening and treatment of advanced stage cervical cancer were featured in the opening plenary session of the American Society of Clinical Oncology Annual Meeting. As such, a review of the evolution of chemotherapy in the treatment of this disease is warranted.

Recent findings: Following the establishment of cisplatin as an effective single-agent regimen in patients with advanced stage, recurrent, or persistent cervical cancer, several platinum-containing combinations were studied. Ultimately, the adoption of cisplatin chemosensitizing radiation resulted in relative ‘cisplatin resistance’ and the concept of nonplatinum doublets emerged as an active area of investigation.

Summary: In an era of biologics, combined therapy with cytotoxic drugs and molecular targeted agents, as well as the use of nonplatinum doublets, represent an exciting area yet to be fully explored.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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