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Management of vaginal agenesis

Edmonds, D. Keith

Current Opinion in Obstetrics & Gynecology:
doi: 10.1097/GCO.0b013e328363d67f
ADOLESCENT AND PEDIATRIC GYNECOLOGY: Edited by Paula J. Adams Hillard
Abstract

Purpose of review: Mayer–Rokitansky–Küster–Hauser syndrome is undergoing new research outcomes involving genetics and management.

Recent findings: Recent literature supports a polygenic multifactorial genetic basis for the syndrome. Management is now predominantly by vaginal dilators and nonsurgical, but holistic. The future of uterine transplantation is discussed.

Summary: New developments open new possibilities for understanding the genetic basis of the disease, and research in this area will continue. Management in terms of fertility may have an added dimension if uterine transplantation and successful pregnancy outcome can be proven.

Author Information

Queen Charlotte's and Chelsea Hospital, London, UK

Correspondence to Mr. D. Keith Edmonds, Consultant Obstetrician and Gynaecologist, Queen Charlotte's and Chelsea Hospital, Du Cane Road, London, W12 0HS, UK. Tel: +44 203 313 3586; fax: +44 203 313 3419; e-mail: DouglasKeith.Edmonds@imperial.nhs.uk

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins